Ernest and Rebecca by Guillaume Bianco. My daughter and I have read the
first two books in this juvenile graphic novel series. Rebecca is a
child with a weak constitution and divorcing parents and an absolutely
fabulous sense of justice. Once befriending the “Ernest” germ, Rebecca
goes about trying to reconcile her parents through all sorts of
ridiculous schemes. My favorite parts, however, are her attempts to
protect Ernest by beating up her doctor and keeping herself sick
(sunbathing in the snow, etc). The author does a great job balancing the
silliness with underlying family turmoil. Antonello Dalena’s
illustrations are fabulous too: brightly colored and clearly emotive.
This should probably be read by any family struggling with divorce or long-term illness or anyone who needs perspective with a laugh.

Another good series (according to my daughter and husband) is
Cat's Cradle by Jo Rioux. The second one isn't in print yet but you can read it online. With such beautiful illustrations, I don't really care what it's about!
Other favorites of my daughters that I seem okay but I can't honestly say I've read them (smile):



Chi's Sweet Home (cute cat, simple, what else do you need? I guess it's been made into an anime but we haven't seen it yet - DON'T tell the kids!)
Jellaby (won a Shuster)
Tiny Titans (even the 3-yr-old gets a kick out of this one and I think it won an Eisner or two)
Bone (loved by all - 10 Eisners! and 11 Harvey Awards!)